Construction of a flagellum-negative mutant of Proteus mirabilis: effect on internalization by human renal epithelial cells and virulence in a mouse model of ascending urinary tract infection.

To examine the role of flagella in pathogenesis of urinary tract infection caused by Proteus mirabilis, we constructed a nonmotile, nonswarming flagellum mutant of strain WPM111 (an hpmA hemolysin mutant of strain BA6163, chosen because of its lack of in vitro cytotoxicity in renal epithelial cell i...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Mobley, H L, Belas, R, Lockatell, V, Chippendale, G, Trifillis, A L, Johnson, D E, Warren, J W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174527/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8945585/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.64.12.5332-5340.1996
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