Attenuated virulence of uridine-uracil auxotrophs of Aspergillus fumigatus.

Aspergillus fumigatus mutants that are deficient in the de novo UMP biosynthesis pathway because of a mutation in the pyrG gene encoding orotidine-5'-phosphate decarboxylase (and therefore auxotrophic for uridine or uracil) were evaluated in a murine model of invasive aspergillosis. These mutants we...

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Pubblicato in:	Infect Immun
Autori principali:	D'Enfert, C, Diaquin, M, Delit, A, Wuscher, N, Debeaupuis, J P, Huerre, M, Latge, J P
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174389/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8926121/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.64.10.4401-4405.1996
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