Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses.

Mucosal immunoglobulin A (IgA) responses are often associated with Th2-type cells and derived cytokines, and interleukin-4 (IL-4) knockout (IL-4-/-) mice with impaired Th2 cells respond poorly to oral antigens. However, we have noted that IL-4-/- mice have normal mucosal IgA levels, which led us to...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Okahashi, N, Yamamoto, M, Vancott, J L, Chatfield, S N, Roberts, M, Bluethmann, H, Hiroi, T, Kiyono, H, McGhee, J R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC173956/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8613355/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.64.5.1516-1525.1996
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