Furin regulates both the activation of Pseudomonas exotoxin A and the Quantity of the toxin receptor expressed on target cells.

Pseudomonas exotoxin A (PE) binds and enters mammalian cells via the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP). The toxin then requires proteolytic cleavage to generate an enzymatically active fragment with translocates to the cell cytosol and inhibits pro...

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Publicado en:	Infect Immun
Autores principales:	Gu, M, Gordon, V M, Fitzgerald, D J, Leppla, S H
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1996
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC173796/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8550202/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.64.2.524-527.1996
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