Protease cleavage of iron-transferrin augments pyocyanin-mediated endothelial cell injury via promotion of hydroxyl radical formation.

Although a number of bacterium- and host-derived factors have been suggested to contribute to the pathogenesis of Pseudomonas aeruginosa-associated tissue injury, the mechanism remains unclear. We have previously shown that protease modification of iron (Fe)-transferrin generates new iron chelates c...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Miller, R A, Rasmussen, G T, Cox, C D, Britigan, B E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC173744/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8557338/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.64.1.182-188.1996
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