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Is the Ala12 variant of the PPARG gene an "unthrifty allele"?

Background: The thrifty genotype hypothesis proposes that genetic susceptibility to type 2 diabetes results from the positive selection of "thrifty" alleles in the past. A corollary of this hypothesis is that genetic variants protecting against the development of diabetes are "unthrif...

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Détails bibliographiques
Auteur principal: Ruiz-Narvaez, E
Format: Artigo
Langue:Inglês
Publié: BMJ Group 2005
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1736098/
https://ncbi.nlm.nih.gov/pubmed/15994875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2004.026765
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