Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families

Objective: To analyse somatic molecular changes, clinicopathological features, family history, and germline mutations in families with colorectal cancer (CRC). Methods: Molecular changes (K-ras and ß-catenin mutations, chromosome 18q allele loss (LOH), APC LOH, microsatellite instability (MSI), and...

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Hlavní autoři: Johnson, V, Lipton, L, Cummings, C, Eftekhar, S, Izatt, L, Hodgson, S, Talbot, I, Thomas, H, Silver, A, Tomlinson, I
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Group 2005
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1735937/
https://ncbi.nlm.nih.gov/pubmed/15788729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2005.031245
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