A new scoring system for the chances of identifying a BRCA1/2 mutation outperforms existing models including BRCAPRO

Methods: DNA samples from affected subjects from 422 non-Jewish families with a history of breast and/or ovarian cancer were screened for BRCA1 mutations and a subset of 318 was screened for BRCA2 by whole gene screening techniques. Using a combination of results from screening and the family histor...

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Hlavní autoři: Evans, D, Eccles, D, Rahman, N, Young, K, Bulman, M, Amir, E, Shenton, A, Howell, A, Lalloo, F
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Group 2004
Témata:
Medical Genetics in Practice
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1735807/
https://ncbi.nlm.nih.gov/pubmed/15173236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2003.017996
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