A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions

Background: Inactivation of the human type Iα regulatory subunit (RIα) of cyclic AMP dependent protein kinase (PKA) (PRKAR1A) leads to altered kinase activity, primary pigmented nodular adrenocortical disease (PPNAD), and sporadic adrenal and other tumours. Methods and results: A transgenic mouse ca...

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Bibliografiska uppgifter
Huvudupphovsmän: Griffin, K, Kirschner, L, Matyakhina, L, Stergiopoulos, S, Robinson-White, A, Lenherr, S, Weinberg, F, Claflin, E, Batista, D, Bourdeau, I, Voutetakis, A, Sandrini, F, Meoli, E, Bauer, A, Cho-Chung, Y, Bornstein, S, Carney, J, Stratakis, C
Materialtyp: Artigo
Språk:Inglês
Publicerad: BMJ Group 2004
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1735656/
https://ncbi.nlm.nih.gov/pubmed/15591278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2004.028043
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