A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions

Background: Inactivation of the human type Iα regulatory subunit (RIα) of cyclic AMP dependent protein kinase (PKA) (PRKAR1A) leads to altered kinase activity, primary pigmented nodular adrenocortical disease (PPNAD), and sporadic adrenal and other tumours. Methods and results: A transgenic mouse ca...

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Detalhes bibliográficos
Main Authors: Griffin, K, Kirschner, L, Matyakhina, L, Stergiopoulos, S, Robinson-White, A, Lenherr, S, Weinberg, F, Claflin, E, Batista, D, Bourdeau, I, Voutetakis, A, Sandrini, F, Meoli, E, Bauer, A, Cho-Chung, Y, Bornstein, S, Carney, J, Stratakis, C
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2004
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1735656/
https://ncbi.nlm.nih.gov/pubmed/15591278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2004.028043
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