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Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas

Background: Paragangliomas are rare and highly heritable tumours of neuroectodermal origin that often develop in the head and neck region. Germline mutations in the mitochondrial complex II genes, SDHB, SDHC, and SDHD, cause hereditary paraganglioma (PGL). Methods: We assessed the frequency of SDHB,...

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Autori principali: Baysal, B, Willett-Brozick, J, Lawrence, E, Drovdlic, C, Savul, S, McLeod, D, Yee, H, Brackmann, D, Slattery, W, Myers, E, Ferrell, R, Rubinstein, W
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Group 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1735061/
https://ncbi.nlm.nih.gov/pubmed/11897817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.39.3.178
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