Binding of lipopolysaccharide (LPS) to an 80-kilodalton membrane protein of human cells is mediated by soluble CD14 and LPS-binding protein.

Activation of cells by bacterial lipopolysaccharide (LPS) plays a key role in the pathogenesis of gram-negative septic shock. The 55-kDa glycoprotein CD14 is known to bind LPS and initiate cell activation. However, there must be additional LPS receptors because CD14 is linked by a glycosylphosphatid...

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Autores principales: Schletter, J, Brade, H, Brade, L, Krüger, C, Loppnow, H, Kusumoto, S, Rietschel, E T, Flad, H D, Ulmer, A J
Formato: Artigo
Lenguaje:Inglês
Publicado: 1995
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC173345/
https://ncbi.nlm.nih.gov/pubmed/7540597
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