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Binding of lipopolysaccharide (LPS) to an 80-kilodalton membrane protein of human cells is mediated by soluble CD14 and LPS-binding protein.

Activation of cells by bacterial lipopolysaccharide (LPS) plays a key role in the pathogenesis of gram-negative septic shock. The 55-kDa glycoprotein CD14 is known to bind LPS and initiate cell activation. However, there must be additional LPS receptors because CD14 is linked by a glycosylphosphatid...

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Detalhes bibliográficos
Publicado no:Infect Immun
Principais autores: Schletter, J, Brade, H, Brade, L, Krüger, C, Loppnow, H, Kusumoto, S, Rietschel, E T, Flad, H D, Ulmer, A J
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1995
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC173345/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7540597/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.63.7.2576-2580.1995
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