Construction of nontoxic derivatives of cholera toxin and characterization of the immunological response against the A subunit.

Using computer modelling, we have identified some of the residues of the A subunit of cholera toxin (CT) and heat-labile toxin that are involved in NAD binding, catalysis, and toxicity. Here we describe the site-directed mutagenesis of the CT gene and the construction of CT mutants. Nine mutations o...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Fontana, M R, Manetti, R, Giannelli, V, Magagnoli, C, Marchini, A, Olivieri, R, Domenighini, M, Rappuoli, R, Pizza, M
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC173311/
https://ncbi.nlm.nih.gov/pubmed/7768621
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados