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Construction of nontoxic derivatives of cholera toxin and characterization of the immunological response against the A subunit.

Using computer modelling, we have identified some of the residues of the A subunit of cholera toxin (CT) and heat-labile toxin that are involved in NAD binding, catalysis, and toxicity. Here we describe the site-directed mutagenesis of the CT gene and the construction of CT mutants. Nine mutations o...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Fontana, M R, Manetti, R, Giannelli, V, Magagnoli, C, Marchini, A, Olivieri, R, Domenighini, M, Rappuoli, R, Pizza, M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1995
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC173311/
https://ncbi.nlm.nih.gov/pubmed/7768621
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