A mutation at histidine residue 135 of toxic shock syndrome toxin yields an immunogenic protein with minimal toxicity.

Structure-function studies have revealed that the region between amino acids 115 and 141 of toxic shock syndrome toxin 1 (TSST-1) constitutes a biologically active domain. A critical residue appears to be histidine 135, since a site-directed mutation that alters the histidine to alanine (H135A) resu...

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Bibliografische gegevens

Gepubliceerd in:	Infect Immun
Hoofdauteurs:	Bonventre, P F, Heeg, H, Edwards, C K, Cullen, C M
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 1995
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC173024/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7822015/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.63.2.509-515.1995
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