Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases.

Before intoxication can occur, anthrax toxin protective antigen (PA), Pseudomonas exotoxin A (PE), and diphtheria toxin (DT) must be activated by proteolytic cleavage at specific amino acid sequences. Previously, it was shown that PA and DT can be activated by furin. In Chinese hamster ovary (CHO) c...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Gordon, V M, Klimpel, K R, Arora, N, Henderson, M A, Leppla, S H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172960/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7806387/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.63.1.82-87.1995
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