Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases.

Before intoxication can occur, anthrax toxin protective antigen (PA), Pseudomonas exotoxin A (PE), and diphtheria toxin (DT) must be activated by proteolytic cleavage at specific amino acid sequences. Previously, it was shown that PA and DT can be activated by furin. In Chinese hamster ovary (CHO) c...

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書誌詳細

出版年:	Infect Immun
主要な著者:	Gordon, V M, Klimpel, K R, Arora, N, Henderson, M A, Leppla, S H
フォーマット:	Artigo
言語:	Inglês
出版事項:	American Society for Microbiology (ASM) 1995
主題:	Research Article
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172960/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7806387/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.63.1.82-87.1995
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