Knockout mutants of Actinobacillus pleuropneumoniae serotype 1 that are devoid of RTX toxins do not activate or kill porcine neutrophils.

The Actinobacillus pleuropneumoniae RTX-toxins ApxI, ApxII, and ApxIII are important virulence factors of this swine pathogen. It is hypothesized that the Apx toxins are deleterious to defense cells of the host, enabling the bacterium to infect the host. To confirm this, we studied the effect on por...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Jansen, R, Briaire, J, Smith, H E, Dom, P, Haesebrouck, F, Kamp, E M, Gielkens, A L, Smits, M A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172953/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7806365/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.63.1.27-37.1995
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