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Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide

AIM—We evaluated the effect of coadministration of sulphasalazine, mesalamine, and balsalazide on the pharmacokinetics and pharmacodynamics of azathioprine and 6-mercaptopurine.
METHODS—Thirty four patients with Crohn's disease receiving azathioprine or 6-mercaptopurine were enrolled in an eigh...

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Detalhes bibliográficos
Main Authors: Lowry, P, Franklin, C, Weaver, A, Szumlanski, C, Mays, D, Loftus, E, Tremaine, W, Lipsky, J, Weinshilboum, R, Sandborn, W
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1728490/
https://ncbi.nlm.nih.gov/pubmed/11600468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.49.5.656
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