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Antisense treatment directed against mutated Ki-ras in human colorectal adenocarcinoma
BACKGROUND—Kirsten ras (Ki-ras) mutations are common in gastrointestinal cancer and one codon 12 mutation, glycine to valine, is particularly aggressive in colorectal cancer. AIMS—To investigate if this valine point mutation could be targeted with antisense oligonucleotides and to determine the effi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1728205/ https://ncbi.nlm.nih.gov/pubmed/11156646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.48.2.230 |
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