Gene amplification contributes to sulfonamide resistance in Escherichia coli.

A sulfathiazole-resistant strain of Escherichia coli was isolated and shown to contain a fourfold tandemly amplified segment of DNA 18 kilobase pairs in length in addition to a mutationally altered dihydropteroate synthase, the target enzyme for sulfonamide inhibition. The amplified DNA contained a...

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Dades bibliogràfiques

Publicat a:	Antimicrob Agents Chemother
Autors principals:	Nichols, B P, Guay, G G
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 1989
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172819/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2694948/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.33.12.2042
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