Gene amplification contributes to sulfonamide resistance in Escherichia coli.
A sulfathiazole-resistant strain of Escherichia coli was isolated and shown to contain a fourfold tandemly amplified segment of DNA 18 kilobase pairs in length in addition to a mutationally altered dihydropteroate synthase, the target enzyme for sulfonamide inhibition. The amplified DNA contained a...
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| Pubblicato in: | Antimicrob Agents Chemother |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology (ASM)
1989
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172819/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2694948/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.33.12.2042 |
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