Autoantibodies against the specific epitope of human tropomyosin(s) detected by a peptide based enzyme immunoassay in sera of patients with ulcerative colitis show antibody dependent cell mediated cytotoxicity against HLA-DPw9 transfected L cells

BACKGROUND AND AIMS—Recent studies suggest that tropomyosin (TM) may act as a putative autoantigen in ulcerative colitis (UC). Recently, we identified, by computer homology analysis, a specific peptide (HIAEDADRK) in human TM that can bind to HLA-DPw9. The aim of this study was to investigate the pr...

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Main Authors: Sakamaki, S, Takayanagi, N, Yoshizaki, N, Hayashi, S, Takayama, T, Kato, J, Kogawa, K, Yamauchi, N, Takemoto, N, Nobuoka, A, Ayabe, T, Kohgo, Y, Niitsu, Y
Format: Artigo
Jezik:Inglês
Izdano: 2000
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1727987/
https://ncbi.nlm.nih.gov/pubmed/10896915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.47.2.236
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