In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone.

AT-4140, 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(cis-3,5- dimethyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid, showed broad and potent antibacterial activity. Its MICs for 90% of the strains tested were 0.1 to 0.78 micrograms/ml against gram-positive organisms, such as members of the...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Nakamura, S, Minami, A, Nakata, K, Kurobe, N, Kouno, K, Sakaguchi, Y, Kashimoto, S, Yoshida, H, Kojima, T, Ohue, T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172618/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2802544/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.33.8.1167
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