In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone.

AT-4140, 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(cis-3,5- dimethyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid, showed broad and potent antibacterial activity. Its MICs for 90% of the strains tested were 0.1 to 0.78 micrograms/ml against gram-positive organisms, such as members of the...

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Autors principals: Nakamura, S, Minami, A, Nakata, K, Kurobe, N, Kouno, K, Sakaguchi, Y, Kashimoto, S, Yoshida, H, Kojima, T, Ohue, T
Format: Artigo
Idioma:Inglês
Publicat: 1989
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC172618/
https://ncbi.nlm.nih.gov/pubmed/2802544
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