Influence of protein binding on therapeutic efficacy of cefoperazone.

The effect of protein binding of cefoperazone (89.3% bound to rabbit serum) on antibacterial activity in serum was tested in a model that simulated a closed-space infection in a neutropenic host. Four gram-negative bacilli were tested in the model with cefoperazone doses of 20 and 200 mg/kg administ...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Peterson, L R, Moody, J A, Fasching, C E, Gerding, D N
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1989
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172480/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2729948/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.33.4.566
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