Selective CXCR4 antagonism by Tat: Implications for in vivo expansion of coreceptor use by HIV-1

Chemokines and chemokine receptors play important roles in HIV-1 infection and tropism. CCR5 is the major macrophage-tropic coreceptor for HIV-1 whereas CXC chemokine receptor 4 (CXCR4) serves the counterpart function for T cell-tropic viruses. An outstanding biological mystery is why only R5-HIV-1...

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Bibliographic Details
Main Authors: Xiao, Hua, Neuveut, Christine, Tiffany, H. Lee, Benkirane, Monsef, Rich, Elizabeth A., Murphy, Philip M., Jeang, Kuan-Teh
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2000
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC17223/
https://ncbi.nlm.nih.gov/pubmed/11027346
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