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Disposition of amopyroquin in rats and rabbits and in vitro activity against Plasmodium falciparum.

The disposition of amopyroquin was studied in rats after a single 50-mg/kg (body weight) oral dose of amopyroquin base. After a rapid absorption phase, the drug concentrations decreased in the plasma, with a terminal half-life of 14.5 h. The drug was widely distributed in the liver and lungs and, to...

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書目詳細資料
發表在:Antimicrob Agents Chemother
Principais autores: Pussard, E, Verdier, F, Faurisson, F, Clavier, F, Simon, F, Gaudebout, C
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 1988
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在線閱讀:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172222/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3288115/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.32.4.568
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