Disposition of amopyroquin in rats and rabbits and in vitro activity against Plasmodium falciparum.
The disposition of amopyroquin was studied in rats after a single 50-mg/kg (body weight) oral dose of amopyroquin base. After a rapid absorption phase, the drug concentrations decreased in the plasma, with a terminal half-life of 14.5 h. The drug was widely distributed in the liver and lungs and, to...
Gespeichert in:
| Veröffentlicht in: | Antimicrob Agents Chemother |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology (ASM)
1988
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172222/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3288115/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.32.4.568 |
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