Potent antipneumocystis and antitoxoplasma activities of piritrexim, a lipid-soluble antifolate.

Piritrexim, a lipid-soluble antifolate, was evaluated for its activity against Pneumocystis carinii and Toxoplasma gondii. The concentration of piritrexim needed to inhibit 50% of the catalytic activity of P. carinii dihydrofolate reductase (DHFR) was 19.3 nM, and that for T. gondii DHFR was 17.0 nM...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Kovacs, J A, Allegra, C J, Swan, J C, Drake, J C, Parrillo, J E, Chabner, B A, Masur, H
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1988
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172195/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2967669/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.32.4.430
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