Pharmacokinetics of fluconazole in cerebrospinal fluid and serum in human coccidioidal meningitis.

The pharmacokinetics of fluconazole, a new oral azole, were evaluated in cerebrospinal fluid and sera of eight patients with coccidioidal meningitis. At a dose of 50 mg/day, peak concentrations of 2.5 to 3.5 and 2.0 to 2.3 micrograms/ml occurred at 2 to 6 and 4 to 8 h in serum and cerebrospinal flui...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Tucker, R M, Williams, P L, Arathoon, E G, Levine, B E, Hartstein, A I, Hanson, L H, Stevens, D A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172178/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2835002/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.32.3.369
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