Bioavailability of oral trimetrexate in patients with acquired immunodeficiency syndrome.

The combination of the lipophilic antifolate trimetrexate and the rescue agent leucovorin has shown promise in the treatment of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. The pharmacokinetic behavior of trimetrexate administered either by intravenous bolus or...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Rogers, P, Allegra, C J, Murphy, R F, Drake, J C, Masur, H, Poplack, D G, Chabner, B A, Parrillo, J E, Lane, H C, Balis, F M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1988
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172168/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2966610/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.32.3.324
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