Cilofungin (LY121019) shows nonlinear plasma pharmacokinetics and tissue penetration in rabbits.

We studied the plasma pharmacokinetics and tissue penetration of cilofungin (LY121019), a new echinocandin antifungal compound, by intermittent and continuous infusion in rabbits. Following a single intravenous dose of 50 mg/kg of body weight, the maximum concentration in plasma was 297 +/- 39 micro...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Lee, J W, Kelly, P, Lecciones, J, Coleman, D, Gordee, R, Pizzo, P A, Walsh, T J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172029/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2073114/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.34.11.2240
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