In vitro activity of sparfloxacin (CI-978; AT-4140) for clinical Legionella isolates, pharmacokinetics in guinea pigs, and use to treat guinea pigs with L. pneumophila pneumonia.

The activities of sparfloxacin, ciprofloxacin, and erythromycin for 21 clinical Legionella isolates were determined by agar and broth dilution susceptibility testing and by growth inhibition assays in guinea pig alveolar macrophages (sparfloxacin and ciprofloxacin). All three antimicrobial agents ha...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Edelstein, P H, Edelstein, M A, Weidenfeld, J, Dorr, M B
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172010/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2073101/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.34.11.2122
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