Intracellular unesterified arachidonic acid signals apoptosis

Cyclooxygenase-2 (COX-2) is up-regulated in many cancers and is a rate-limiting step in colon carcinogenesis. Nonsteroidal antiinflammatory drugs, which inhibit COX-2, prevent colon cancer and cause apoptosis. The mechanism for this response is not clear, but it might result from an accumulation of...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Cao, Yang, Pearman, A. Terrece, Zimmerman, Guy A., McIntyre, Thomas M., Prescott, Stephen M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2000
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17191/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11005842/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.200367597
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