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Is disomic homozygosity at the APECED locus the cause of increased autoimmunity in Down's syndrome?

AIMS—To examine the age of onset of insulin dependent diabetes mellitus (IDDM) in children with Down's syndrome compared with non-trisomic individuals, and to assess whether differences might be related to disomic homozygosity at the autoimmune polyglandular disease type 1 (APECED) gene locus.
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Bibliografische gegevens
Hoofdauteurs: Shield, J., Wadsworth, E., Hassold, T., Judis, L. A., Jacobs, P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMJ Group 1999
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1718036/
https://ncbi.nlm.nih.gov/pubmed/10490523
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