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A biosensor assay for studying ligand-membrane receptor interactions: Binding of antibodies and HIV-1 Env to chemokine receptors

The HIV envelope (Env) protein mediates entry into cells by binding CD4 and an appropriate coreceptor, which triggers structural changes in Env that lead to fusion between the viral and cellular membranes. The major HIV-1 coreceptors are the seven transmembrane domain chemokine receptors CCR5 and CX...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Hoffman, Trevor L., Canziani, Gabriela, Jia, Li, Rucker, Joseph, Doms, Robert W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17180/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11005830/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.190274097
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