A biosensor assay for studying ligand-membrane receptor interactions: Binding of antibodies and HIV-1 Env to chemokine receptors

The HIV envelope (Env) protein mediates entry into cells by binding CD4 and an appropriate coreceptor, which triggers structural changes in Env that lead to fusion between the viral and cellular membranes. The major HIV-1 coreceptors are the seven transmembrane domain chemokine receptors CCR5 and CX...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Hoffman, Trevor L., Canziani, Gabriela, Jia, Li, Rucker, Joseph, Doms, Robert W.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2000
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17180/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11005830/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.190274097
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