High-affinity ouabain binding by a chimeric gastric H(+),K(+)-ATPase containing transmembrane hairpins M3-M4 and M5-M6 of the α(1)-subunit of rat Na(+),K(+)-ATPase

Na(+),K(+)-ATPase and gastric H(+),K(+)-ATPase are two related enzymes that are responsible for active cation transport. Na(+),K(+)-ATPase activity is inhibited specifically by ouabain, whereas H(+),K(+)-ATPase is insensitive to this drug. Because it is not known which parts of the catalytic subunit...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Koenderink, Jan B., Hermsen, Harm P. H., Swarts, Herman G. P., Willems, Peter H. G. M., De Pont, Jan Joep H. H. M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17179/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11016952/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.200109597
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