Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach

Ménétrier disease and gastrointestinal stromal tumors (GISTs) are hyperproliferative disorders of the stomach caused by dysregulated receptor tyrosine kinases (RTKs). In Ménétrier disease, overexpression of TGF-α, a ligand for the RTK EGFR, results in selective expansion of surface mucous cells in t...

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Bibliografiske detaljer
Main Authors: Coffey, Robert J., Washington, Mary Kay, Corless, Christopher L., Heinrich, Michael C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2007
Fag:
Review Series
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1716220/
https://ncbi.nlm.nih.gov/pubmed/17200708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30491
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