Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737

Antiapoptotic B cell leukemia/lymphoma 2 (BCL2) family proteins are expressed in many cancers, but the circumstances under which these proteins are necessary for tumor maintenance are poorly understood. We exploited a novel functional assay that uses BCL2 homology domain 3 (BH3) peptides to predict...

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Autors principals: Del Gaizo Moore, Victoria, Brown, Jennifer R., Certo, Michael, Love, Tara M., Novina, Carl D., Letai, Anthony
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2007
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1716201/
https://ncbi.nlm.nih.gov/pubmed/17200714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28281
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