Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposis.

PTEN, a protein tyrosine phosphatase with homology to tensin, is a tumor-suppressor gene on chromosome 10q23. Somatic mutations in PTEN occur in multiple tumors, most markedly glioblastomas. Germ-line mutations in PTEN are responsible for Cowden disease (CD), a rare autosomal dominant multiple-hamar...

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Detalhes bibliográficos
Main Authors: Lynch, E D, Ostermeyer, E A, Lee, M K, Arena, J F, Ji, H, Dann, J, Swisshelm, K, Suchard, D, MacLeod, P M, Kvinnsland, S, Gjertsen, B T, Heimdal, K, Lubs, H, Møller, P, King, M C
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1716102/
https://ncbi.nlm.nih.gov/pubmed/9399897
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