Hereditary nonpolyposis colorectal cancer families not complying with the Amsterdam criteria show extremely low frequency of mismatch-repair-gene mutations.

Hereditary nonpolyposis colorectal cancer (HNPCC) is a common autosomal dominant cancer-susceptibility condition characterized by early onset colorectal cancer. Germ-line mutations in one of four DNA mismatch repair (MMR) genes, hMSH2, hMLH1, hPMS1, or hPMS2, are known to cause HNPCC. Although many...

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Bibliographic Details
Main Authors: Wijnen, J, Khan, P M, Vasen, H, van der Klift, H, Mulder, A, van Leeuwen-Cornelisse, I, Bakker, B, Losekoot, M, Møller, P, Fodde, R
Format: Artigo
Language:Inglês
Published: 1997
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1715907/
https://ncbi.nlm.nih.gov/pubmed/9311737
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