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Analysis of genetic linkage and somatic loss of heterozygosity in affected pairs of first-degree relatives.

Recently, data on loss of constitutional heterozygosity (LOH) have been used by several groups to increase the power to detect linkage in pedigrees with an inherited cancer predisposition. This approach assumes that the predisposition is due to the inheritance of the defective copy of a tumor suppre...

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Dettagli Bibliografici
Autori principali: Rohde, K, Teare, M D, Santibáñez Koref, M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1997
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1715901/
https://ncbi.nlm.nih.gov/pubmed/9311747
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