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Analysis of genetic linkage and somatic loss of heterozygosity in affected pairs of first-degree relatives.

Recently, data on loss of constitutional heterozygosity (LOH) have been used by several groups to increase the power to detect linkage in pedigrees with an inherited cancer predisposition. This approach assumes that the predisposition is due to the inheritance of the defective copy of a tumor suppre...

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Bibliografski detalji
Glavni autori: Rohde, K, Teare, M D, Santibáñez Koref, M
Format: Artigo
Jezik:Inglês
Izdano: 1997
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1715901/
https://ncbi.nlm.nih.gov/pubmed/9311747
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