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Mechanisms of quinolone resistance in Escherichia coli: characterization of nfxB and cfxB, two mutant resistance loci decreasing norfloxacin accumulation.

Two genetic loci selected for norfloxacin (nfxB) and ciprofloxacin (cfxB) resistance were characterized. Both mutations have previously been shown to confer pleiotropic resistance to quinolones, chloramphenicol, and tetracycline and to decrease expression of porin outer-membrane protein OmpF. nfxB w...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Hooper, D C, Wolfson, J S, Souza, K S, Ng, E Y, McHugh, G L, Swartz, M N
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1989
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171480/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2658782/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.33.3.283
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