The potential for gene repair via triple helix formation
Triplex-forming oligonucleotides (TFOs) can bind to polypurine/polypyrimidine regions in DNA in a sequence-specific manner. The specificity of this binding raises the possibility of using triplex formation for directed genome modification, with the ultimate goal of repairing genetic defects in human...
Spremljeno u:
| Izdano u: | J Clin Invest |
|---|---|
| Glavni autori: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Clinical Investigation
2003
|
| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171401/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12925687/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI19552 |
| Oznake: |
Bez oznaka, Budi prvi tko označuje ovaj zapis!
|