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Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis
Stepwise degradation of the invariant chain (Ii) is required for the binding of antigenic peptides to MHC class II molecules. Cathepsin (Cat) L in the murine thymus and Cat S in peripheral APCs have both been implicated in the last step of Ii degradation that gives rise to the class II–associated in...
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Main Authors: | , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Clinical Investigation
2003
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC171390/ https://ncbi.nlm.nih.gov/pubmed/12925692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200318028 |
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