Founder BRCA1 and BRCA2 mutations in Ashkenazi Jews in Israel: frequency and differential penetrance in ovarian cancer and in breast-ovarian cancer families.

Germ-line BRCA1 and BRCA2 mutations account for most of familial breast-ovarian cancer. In Ashkenazi Jews, there is a high population frequency (approximately 2%) of three founder mutations: BRCA1 185delAG, BRCA1 5382insC, and BRCA2 6174delT. This study examined the frequency of these mutations in a...

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Detalhes bibliográficos
Main Authors: Levy-Lahad, E, Catane, R, Eisenberg, S, Kaufman, B, Hornreich, G, Lishinsky, E, Shohat, M, Weber, B L, Beller, U, Lahad, A, Halle, D
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1712434/
https://ncbi.nlm.nih.gov/pubmed/9150153
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