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Method for induction of mutations in physically defined regions of the herpes simplex virus genome.

A procedure was developed for inducing mutations in isolated restriction enzyme fragments of herpes simplex virus type 1 (HSV-1) DNA with nitrous acid. The mutations were then transferred to the viral genome by genetic recombination during cotransfection of rabbit kidney cells with the mutagenized f...

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Detalhes bibliográficos
Publicado no:J Virol
Principais autores: Sandri-Goldin, R M, Levine, M, Glorioso, J C
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1981
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171124/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6264113/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.38.1.41-49.1981
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