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Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro

Assays of drug action typically evaluate biochemical activity. However, accurately matching therapeutic efficacy with biochemical activity is a challenge. High-content cellular assays seek to bridge this gap by capturing broad information about the cellular physiology of drug action. Here, we presen...

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Autores principales: Gunther, Erik C., Stone, David J., Gerwien, Robert W., Bento, Patricia, Heyes, Melvyn P.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2003
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC170965/
https://ncbi.nlm.nih.gov/pubmed/12869696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1632587100
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